The Greet CE project adopts a multidisciplinary approach to smart specialization, aiming to enhance the innovation capacity of regional Small and Medium-sized Enterprises (SMEs), especially in less developed regions of Central Europe and in one outermost European region of of Madeira. The consortium, comprising eight members from seven regions across six Central and Southern European countries, will accelerate the practical ability of regions to base their future development on their unique competitive advantages (resources and assets) and key socio-economic challenges.